Code used in the mathematical model calculations to determine the stable membrane shapes in the paper - YSakaiGH/autophagosome_shapes ...

Autophagy, a natural cellular process, recycles damaged components, boosting health and anti-aging benefits. Fasting, ...

They provide evidence that autophagosome formation is required for the initiation of chloroplast budding, and that stromule formation is not correlated with this process. In addition, the authors also ...

In summary, we here show that using the LC3 turnover assay, our two-step model helps to systematically determine changes in autophagosome formation vs degradation, the net turnover and the size of the ...

We speculated that if Atg1 controls autophagosome–vacuole fusion by phosphorylating Ykt6, then Ykt6 phospho‐mimicking mutants should also prevent autophagosome–vacuole fusion in vitro. To assess the ...

Autophagy is a complex process of intracellular degradation of senescent or malfunctioning organelles. Dysregulated autophagy is associated with certain cancers, neurodegenerative diseases, immune ...

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In view of the above, the group proposes the model that Atg2 tethers pre-autophagosomal membranes (autophagosome precursors) to the endoplasmic reticulum, initiates autophagosome formation, and ...

The membrane origin and the cellular localization of autophagosome biogenesis will be also considered. Hence, in this article we present an overview of the current knowledge of the molecular ...

The molecular mechanism of autophagosome biogenesis remains poorly understood. Previous studies have shown that Atg2 forms a complex with the phosphatidylinositol 3-phosphate (PI3P)-binding protein ...