Abstract: Autophagy is a catabolic mechanism responsible for transporting cytoplasmic components to lysosomes for degradation. This study employs two-photon microscopy to investigate autophagosomes in ...

COVID-19 vaccination has been the subject of immense scrutiny and misinformation since the vaccines were first administered in the U.S. nearly four years ago. In the first year alone, it is estimated ...

Upon autophagy induction, ZDHHC13 is recruited to autophagosome formation sites together with ATG9A. ULK1 is palmitoylated at Cys 927 and Cys 1003 residues by ZDHHC13, and the ULK1 complex are ...

A sweeping new definition of long COVID could help affected people get recognition of their condition and improve diagnosis and treatment. The U.S. National Academies of Sciences, Engineering and ...

This paper addresses a fundamental issue in the field of autophagy: how is a protein responsible for autophagosome-lysosome fusion recruited to mature autophagosomes but not immature ones? The work ...

Pre-autophagosome membrane captures damaged mitochondria and other cytosolic components to become an autophagosome. Autophagosome fuses with lysosome and the materials inside are degraded. Researchers ...

Forbes contributors publish independent expert analyses and insights. Rachel Wells is a writer who covers leadership, AI, and upskilling. As ambitious leaders and managers take on the new business ...

During macroautophagy, cytoplasmic constituents are engulfed by autophagosomes. Lysosomes fuse with closed autophagosomes but not with unclosed intermediate structures. This is achieved in part by the ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Obesity and metabolic syndrome are commonly associated with an increased risk of cardiovascular disease. Obesity-induced cardiomyopathy is characterized by morphological, functional, and metabolic ...