Bernstein Liebhard LLP, a nationally acclaimed investor rights law firm, reminds Compass Group Diversified Holdings, LLC, and Compass Diversified Holdings (“Compass” or ...

Complement activation was common but non-specific in immune-related neuropathy and myositis, questioning the utility of complement inhibitors.

补体系统作为免疫防御的核心机制，其过度激活会引发血栓性微血管病等致命性疾病。其中，可溶性C5b-9（sC5b-9）作为末端补体复合物（Terminal Complement Complex, TCC）的循环标志物，已成为评估补体激活程度和治疗效果的关键指标。然而，现有检测方法存在线性范围窄、抗干扰能力差异大等问题，尤其 ...

Eculizumab: Efficacy and Safety in PNH Eculizumab is a humanized monoclonal antibody that targets the C5 complement protein, preventing its cleavage into C5a and C5b. This inhibits the formation of ...

Conclusion This is the first study to demonstrate evidence in non-lesional skin of microvascular C5b-9 indicative of systemic complement pathway activation in LN. C5b-9 deposition is statistically ...

This study assessed the predictive potential of complement factors C3a and C5b-9 for COVID-19 progression and outcome. We grouped 80 COVID-19 patients into severe COVID-19 patients (n = 38) and ...

C5b-9 can form a transmembrane channel in the cell membrane and induce target cell lysis by changing the osmotic pressure (Serna et al., 2016). On the other hand, in response to various regulatory ...

Keywords: complement, cancer, metastasis, C5b-9, C1q, C3a, C5a, complement regulatory proteins Citation: Rolfe BE, Pio R, Woodruff TM, Markiewski MM and Manthey HD (2020) Editorial: The Role of ...

Deposition of the terminal complement proteins (C5b-9) on human endothelial cells can result in cell lysis or nonlytic alterations of cell function including procoagulant responses. Because regulation ...