The commonest and most practised medications offered to those suffering from Parkinson’s disease focus primarily on symptom ...

A new role of calcium in the development of muscles has been reported by two RIKEN biologists.

Electroacupuncture (EA) has both anti-inflammatory and cardio-protective effects. Activation of calpain pathway is involved in several myocardiopathy. In sepsis, the role of calpain-2-regulated STAT3 ...

AMX0014, meanwhile, is a calpain-2-targeting antisense drug, in late preclinical development, with an initial clinical trial due to start before year-end. “Our pipeline is supported by ...

Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are major complications that occur in severely ill patients who require intensive care treatment. CIP and CIM affect the ...

[1]. Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4. [2]. Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ...

Nuclear depletion, abnormal modification, and cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP-43) are linked to a group of fatal neurodegenerative diseases called TDP-43 proteinopathies, ...

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead ...