The macroscopic dissociation constant for the enzyme–Tris complex that results in the formation of the C4a-S-cysteinyl-flavin (Kdapp) determined in this study is ∼14 mM at pH 8.0 (Table 1). The ...

Hong Qian, Ph.D, professor in Molecular Hematology, a group leader for the research group Leukemia niche [1] at the Center for Hematology and Regenerative Medicine (HERM) at Karolinska Institutet.

The cysteinyl LTs exert their biological action by binding to two types of G-protein-coupled 7-transmembrane receptors, CysLT1 and CysLT2.

Correction for “Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4,” by Mengting Jiang, Youwei Xu, Xiaodong Luan, Kai Wu, Zhen Li, H. Eric Xu, Shuyang Zhang, Yi Jiang, ...

Total chemical synthesis provides a unique approach for the access to uncontaminated, monodisperse, and more importantly, post-translationally modified membrane proteins. In the present study we ...