Tecnologico de Monterrey, Institute for Obesity Research, School of Engineering and Sciences, Av. Eugenio Garza Sada 2001, 64849 Monterrey, Nuevo León, México Laboratori de Recerca en Microbiologia i ...

As existing drugs are not specifically targeted at this virus, there is a growing interest in exploring natural antimicrobial peptides such as defensin as potential therapeutic options. Human β ...

图 基于多组学的人肠道α防御素5（HD5）与志贺菌互作机制及干预策略研究框架图 ...

New research in eGastroenterology identifies the unfolded protein response (UPR) as a crucial mechanism in maintaining ...

Correspondence to: Dr P T G Elkington Department of Infectious Diseases, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; p.elkington{at}imperial.ac.uk Matrix ...

杂志上以封面文章发表题为《人肠道防御素HD5与结肠上皮受体 P2Y11 的相互作用促进志贺菌感染》（Shigella infection is facilitated by interaction of human enteric α- ...

本研究首次揭示了人肠道防御素HD5通过促进志贺菌吸附和入侵的分子机制，破解了志贺菌缺乏传统吸附装置却能在人体肠道中高效特异入侵的“难解之谜”；鉴定出P2Y11为HD5的功能性受体，填补了肠道防御素特异性受体研究的空白；探索出一套宿主-病原体互作多组学研究体系，为解析复杂感染机制提供了方法论范例。从进化角度来看，防御素的演化史如同一部缩略的“生存手册”，记录了早期人类如何通过分子创新应对生态剧变，但 ...

Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory conditions that are immunologically mediated. Although their exact etiologies remain uncertain, results from ...

Notably, less secretion of α-defensin by Paneth cells is linked to the pathogenesis of Crohn's disease in patients with mutation of the gene encoding Nod2 (ref. 6).

Unlike organ transplants where an immunosuppressive environment is required, a successful pregnancy involves an extremely robust, dynamic, and responsive maternal immune system to maintain the ...

Gut microbial colonization starts with birth and initiates a complex process between the host and the microbiota. Successful co-development of both establishes a symbiotic mutual relationship and ...