The concept of using vaccines to treat cancers has been around for several decades. A vaccine was first approved for prostate cancer in 2010, and another was approved in 2015 for melanoma. Since then, ...

1Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 2Department of Breast and Thyroid Surgery, The First ...

The animal ethics committee of VIB Inflammation Research Center and University Hospital Ghent approved all experiments. Bone marrow cells were freshly isolated from femur and tibia by crushing in RPMI ...

These studies illustrate that encounters of B cells with antigen in these organs can be facilitated by diffusion of the antigen or by the presentation of antigen by macrophages, dendritic cells ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...

1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

Antigen processing and presentation is the mechanism by which whole antigens are degraded and loaded onto MHC molecules for display on the cell surface for recognition by T cells. Both macrophages ...

However, dendritic cells (DCs), which rely on a specialized endocytic machinery that confers ... of MHC class I in DCs remains poorly understood and should be further studied because of its likely ...

State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China Department of Andrology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical ...