Background: Adefovir dipivoxil (ADV) is a potent nucleotide analogue against both the wild-type and lamivudine (LMV) resistant hepatitis B virus (HBV). The cumulative incidence of ADV resistant ...

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Adefovir dipivoxil, a marketed drug for the treatment of hepatitis B, is dosed at submaximally efficacious doses because of renal toxicity. In an effort to improve the therapeutic index of adefovir, 1 ...

Prodrugs are bioreversible derivatives of drug molecules that must undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert its desired ...

BPT propyl ester (propyl 2-(3-cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylate) was synthesized, and the solvent effect in the polymorphic crystallization of the BPT propyl ester was ...

Goal of Treatment Various antiviral therapies can lead to normalization of serum alanine aminotransferase (ALT), hepatitis B virus (HBV) DNA suppression, hepatitis B e antigen (HBeAg ...

Table 1. Commercial assays available for HBV DNA quantitation. Method Commercial kits Lower limit of detection Ref. If ALT becomes persistently elevated, consider biopsy, especially in individuals ...

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