Day 90 biopsy data reported from first 3 participants dosed in Phase 1/2 INSPIRE DUCHENNE trial —— Average microdystrophin expression of 110% ...

Solid Biosciences (SLDB) announced initial data from the Phase 1/2 INSPIRE DUCHENNE trial evaluating SGT-003, a next-generation gene therapy ...

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform ...

The study further delineates the role of epigenetic readers from the bromoterminal and extraterminal domain (BET) protein family such as Brd2 and Brd4, which recognise and interact with acetylated ...

To understand the organization of the utrophin complex at neuromuscular junctions ... this connection because other syntrophin-associated proteins (dystrophin and utrophin) were less stringently ...

Background: Dystrophin is a key protein encoded by the DMD gene ... The SVM classifier combines protein sequence, profile, and functional data to differentiate between disease-associated and neutral ...

By chemically building aged biomolecules like proteins and working to identify the 'tipping point' of when wear-and-tear irreparably impedes the function of chromatin and other complex cellular ...

Amyloidosis is a disease complex characterized by the deposition of protein fibrils in various organs, which leads to structural and functional derangement. There are various types of amyloidosis ...

The laminin binding protein dystroglycan plays multiple roles in cell adhesion ... Current efforts are centred around characterising a role as part of the LINC complex in the inner nuclear membrane.

Objective Events triggering disease outbreak in individuals at-risk for rheumatoid arthritis (RA at-risk) remain unclear, and the role of the various anticitrullinated protein antibody (ACPA ... IgA1, ...

Additionally, the risk of weight gain from high-fat and high-carb foods can lead to less control of blood sugar levels. Simple vs. Complex Carbs The American Diabetes Association recommends eating ...