为解决 TP53 移码突变胃癌治疗难题，江南大学附属医院研究人员开展相关研究，发现 GSK690 可抑制 TP53 Frameshift NLS 胃癌细胞生长。该成果为这类患者提供新治疗策略，极具科研价值，推荐大家阅读。

近日， 团队 在国际知名期刊 PNAS 上发表了题为 “ A frameshift mutation in JAZ10 resolves the growth versus defense dilemma in rice ” 的研 究论文， 在对茉莉酸信号途径 JAZ10 基因的编辑中，意外的发现了一种移码突变产生的新蛋白既提高水稻的生长又提高水稻的抗虫性，并解析了新蛋白的作用机制 ...

Frameshift mutation of the Dok1 gene in CLL. (a) cDNA samples from 11 normal and 46 CLL samples were amplified using the primer set F4/R4 and screened for detection of Dok1 mutation by ...

Frameshift mutations in the RIZ gene were found in 17% of melanoma samples and 8.6% of naevi, but we could not demonstrate any missense mutations in the exons of RIZ1.

If you want to build a foundational understanding of genomics in both health and disease, it's important to be able to distinguish between the different type of genetic mutations that can occur. Here, ...

In a paper published on aBIOTECH, the authors obtained viable knockout mutants with developmental defects by introducing frameshift mutations to C -terminus sequence of three essential protein kinase ...

Frameshift deletion mutation in ORF7a may provide fitness advantage to Australia's SARS-CoV-2 delta variants. News-Medical, viewed 05 December 2024, https: ...

Vaccination of MSI-H colorectal cancer patients with frameshift peptide antigens: A phase I/IIa clinical trial. Matthias Kloor , Miriam Reuschenbach , Julia Karbach , Mohammad-Reza Rafiyan , ...

A recent study by Canadian and US researchers demonstrates how frameshift signals of coronaviruses represent a viable target for developing novel therapeutics with broad-spectrum activity – not ...

Attitudes toward prevention options in Lynch syndrome (LS): Comparing frameshift peptide vaccination (FSPVAX), colonoscopy (COLO), and aspirin (ASA) chemoprevention. Michael J. Hall , Emma D Riggs , ...