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转座子元件或是 HIV-1 精英控制的关键 “幕后推手”
在研究结论和讨论部分,研究人员提出了一个初步模型:在 ECs 中,一些 KZNFs 的表达降低,使得作为抗病毒基因启动子或增强子的 TEs 的顺式调控活性增加,从而提高了先天免疫基因和限制因子的基础表达,增强了对 HIV - 1 的抵抗力。不过,这个模型还需要进一步的实验验证。
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