The roles of risk variants on clinical traits of ACLF were also analysed. Conclusions Our genome-wide association study identified HLA-DR as the major locus for susceptibility to HBV-related ACLF. Our ...

SpecHLA reconstructs entire diploid sequences of HLA genes and infers LOH events. It supports HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, and -DRB1 genes. Also, it ...

There were 244 distinct HLA alleles (142 of Class I and 93 of Class II) comprising the classical genes of Class I (A, B, C) and Class II (DPB1, DQB1, DRB1). The alleles and their frequencies ...

xinhuamed.com.cn Background The classical human leucocyte antigen (HLA) genes were the most important genetic determinant for Graves’ disease (GD). The aim of the study was to fine map causal variants ...

1 Institute of Liver Studies, King's College Hospital, King's College London, London, UK Correspondence to Dr Charalambos G Antoniades, Division of Digestive Diseases, St Mary's Campus, Imperial ...

and HLA-DPB1*01:01 (0.4051). Allelic frequencies were not statistically different between HIV-1 positive and negative subjects. However, we observed alleles present only in subjects living with HIV-1.

and HLA-DPB1*01:01 (0.4051). Allelic frequencies were not statistically different between HIV-1 positive and negative subjects. However, we observed alleles present only in subjects living with HIV-1.

This month's cover highlights the article Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation by Mona Breßer, Kevin D. Siemens, Reiner Schneider and ...

Bones in the chest may also fuse. The exact cause of AS is unknown. But researchers think that genetics play a role. A gene called HLA-B27 is found in most white Americans who have AS. But this gene ...

Accurate Typing of Diverse Immune-Related Gene Families from Long-Read Sequencing Data. It can handle HLA, KIR, IG, TCR, CYP gene families. It supports both WGS and amplicon data. It supports PacBio ...

The expression of class II HLA molecules, which are responsible for antigen presentation to helper T cells, including HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB5, HLA-DMA, HLA-DMB, CD74, and CIITA ...