Metabolic differences observed between iPSCs and ESCs reveal novel pathways important in somatic cell reprogramming. These findings are the first demonstrating that the global metabolomic profiles ...

Our system allowed us to trace multiple discrete reprogramming 'lineages' from parental fibroblast to terminal iPS cell colony. We acquired images over complete 12- or 14-d experiments at 0.25- to ...

A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, safer, and more cost-effective strategy for generating progenitor-like cells from adult cells.

Heart tissue normally can't regenerate after an injury. But now, scientists at Max Planck have shown in mice that reprogramming the energy metabolism of the heart allows it to regenerate after a ...

A Ludwig Cancer Research study has identified a metabolic switch in the immune system's T cells that is essential to the generation of memory T cells—which confer lasting immunity to previously ...

Researchers have identified a hurdle towards an efficient conversion: the cell metabolism. By expressing neuron-enriched mitochondrial proteins at an early stage of the direct reprogramming ...

A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, safer, and more cost-effective strategy for generating progenitor-like cells from adult cells.

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

These activate a kind of metabolic switch in the Kupffer cells and change the way these cells direct liver cells in the long term. "This switch is a so-called transcription factor," says Mass.