尽管PINK1-PARKIN通路下调提示其可能非主要作用靶点，但LC3-II的上调证实自噬体形成增强。 这种“矛盾”现象可能与线粒体分裂-自噬的偶联有关，未来需进一步解析L-NAME对Drp1（线粒体分裂蛋白）等因子的影响。

该研究首次阐明DPSCs通过PINK1/Parkin依赖性线粒体自噬通路，重塑TMJOA滑膜巨噬细胞的免疫平衡：一方面促进M2型极化以抑制炎症，另一方面增强胞葬功能以清除凋亡细胞。

Little is known about the protein constituents of autophagosome membranes in mammalian cells. Here we demonstrate that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of ...

Bcl2-L-13 (Bcl-2-like protein 13), a homolog of yeast Atg32, is a single transmembrane domain OMM protein that was first discovered in mammals by the Otsu research group in 2015. Bcl2-L-13 interacts ...

Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy ...

Introduction Parkin (Park2), an E3 ubiquitin ligase, is critical to maintain mitochondrial function by regulating mitochondrial biogenesis and degradation (mitophagy), but recent evidence suggests the ...

PARKIN: Blame-throwers fired up in wake of pipeline fiasco Rarely has there been such a monumental policy failure as the Trans Mountain pipeline.

Dubai is set to enhance its electric vehicle infrastructure through a strategic collaboration between the Dubai Electricity and Water Authority and Parkin Company PJSC, the city’s leading provider of ...

Autophagy is a catabolic mechanism responsible for transporting cytoplasmic components to lysosomes for degradation. This study employs two-photon microscopy to investigate autophagosomes in starved ...

Kathleen Parkin loved to go on cruises, watching her shows The Y&R and Bold and Beautiful, sweets, animals, and nature specially her pups and all the beautiful birds that she fed and admired.

Derek Parkin OAM has accounting experience spanning over 40 years and across four continents, primarily in the public company environment. Mr Parkin was a national board member of the ICAA and has ...