FCCP induces AMBRA1 binding to LC3 through a previously undisclosed LIR motif, this enhancing PARKIN-mediated mitophagy. As AMBRA1 can localize at the mitochondria, 3 and as this organelle has ...

Parkin and PINK1, proteins mutated in ... Unexpectedly, phase-separated foci formed by p62 or NBR1, rather than those by NDP52 or OPTN, contained more LC3 family proteins.