Lentiviruses pseudotyped with the modified Sindbis virus envelope protein have been shown to bind and enter cells when an appropriate monoclonal antibody is attached. 17, 18, 31, 33 We used this ...

Lentiviruses produced by baculovirus method transduced HeLa cells and showed sustained GFP expression. No evidence of the formation of replication competent lentiviruses was detected by p24 enzyme ...

Lentiviruses, the viral group that includes HIV, are an undeniable scourge. The viruses set up chronic, slow-brewing infections in mammals, typically crippling a subset of immune cells essential ...

In contrast, primate lentiviruses in this evolutionary "arms race" have acquired their own "weapon," viral infectivity factor (Vif), to antagonize the antiviral effect of restriction factors.

This article examines viral and non-viral vectors in gene therapy, highlighting their mechanisms, advantages, and limitations ...

Moreover, this is the first investigation elucidating the molecular mechanism by which great ape lentiviruses achieve cross-species transmission," said the lead scientist, Kei Sato, Associate ...

Lentiviruses exploit a latent state in order to disseminate freely throughout the body and to avoid elimination from the immune system of the host.

But if Gifford and his colleagues find more evidence that lentiviruses and primates have been in each other's genetic business for many millions of years, they could turn that assumption on its head.

However, it remains unclear how primate lentiviruses successfully transmitted among different species. To limit cross-species lentiviral transmission, cellular "intrinsic immunity", including ...

Helmholtz Zentrum München and Sirion Biotech seek to optimize the use of lentiviruses as gene vectors for hematopoietic cells. “We want to specifically refine the lentiviral vectors to target ...

Leprechaun is a state-of-the-art lentivirus titer and characterization platform, for contaminant analysis and much more.