Lentiviruses, the viral group that includes HIV, are an undeniable scourge. The viruses set up chronic, slow-brewing infections in mammals, typically crippling a subset of immune cells essential ...

Cancer Gene Therapy - Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells Skip to main content Thank you for visiting nature.com.

Gene therapy vectors derived from lentiviruses offer many potentially unique advantages over more conventional retroviral gene delivery systems. Principal amongst these is their ability to provide ...

Discovery Of Virus In Lemur Could Shed Light On AIDS Date: December 2, 2008 Source: Stanford University Medical Center Summary: The genome of a squirrel-sized, saucer-eyed lemur from Madagascar ...

Animal lentiviruses are bovine immunodeficiency virus (BIV), caprine arthritis encephalitis virus (CAEV), equine infectious anemia virus (EIAV), feline immunodeficiency virus ...

In contrast, primate lentiviruses in this evolutionary "arms race" have acquired their own "weapon," viral infectivity factor (Vif), to antagonize the antiviral effect of restriction factors.

Researchers discovered that interferon-stimulated SAMD9L restricts HIV-1 and other lentiviruses by inhibiting viral translation and endosomal trafficking, while SAMD9 enhances HIV-1 replication.

This article examines viral and non-viral vectors in gene therapy, highlighting their mechanisms, advantages, and limitations ...

In contrast, primate lentiviruses in this evolutionary "arms race" have acquired their own "weapon," viral infectivity factor (Vif), to antagonize the antiviral effect of restriction factors.

Study: SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation.Image Credit: NIAID. Background. SAMD9 and SAMD9L are paralogous ...