Metabolic pathways articles from across Nature Portfolio Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural ...

This work also demonstrates a new strategy for developing synthetic metabolic pathways: recruiting non-natural biochemical reactions enabled by computationally designed enzymes.

Eolo Pharma plans to initiate Phase 2 clinical trials in 2025 to evaluate SANA’s long-term safety and efficacy as both a standalone and combination therapy for metabolic disease.