研究人员使用携带人类LILRB4转基因且具有淀粉样蛋白（A）沉积的小鼠模型，通过LILRB4靶向单抗进行干预时发现：LILRB4单抗可降低A积累并减轻A相关的行为异常；LILRB4单抗增强了小胶质细胞活性；减少干扰素诱导基因的表达，可以减轻神经炎症。

Microglia play a crucial role in neuroinflammation after ischemic brain injury. Previous data have shown that leukocyte immunoglobulin-like receptor B4 (LILRB4) was upregulated in mice after middle ...

Objective: Microglia, the central nervous system's immune cells, are crucial in neuroinflammation after ischemic brain injury. Previous single-cell and spatial transcriptomics showed that LILRB4 was ...