The research supports an emerging view among scientists that specialized neurons in the body play an important role in the gut-brain connection, which can affect everything from hunger to mood.

When the scientists added tau seeds to iPSC-derived neurons exposed to a variety of ApoE lipoprotein particles, lipofuscin formation and tau fibril internalization went hand-in-hand, with cells ...

A brain circuit made up of three types of neurons may regulate appetite, a mouse study finds.

Oxidative species in company with excessive amounts of intracellular free iron result in Fenton-type reaction with subsequent production of highly reactive hydroxyl radicals which initiate ...

During investigation of endogenous fluorescence of different types of cicatricial deformities in vivo unexpected results on fluorescence of lipofuscin were obtained. Increased lipofuscin fluorescence ...

The human brain's billions of neurons represent a menagerie of cells that are among both the most highly specialized and variable ones in our bodies. Neurons convert electrical signals to chemical ...

Additionally, tomosyn-deficient neurons showed impaired mRNA expression of some DCV cargos, which was not restored by re-expression of tomosyn and was also observed in Cre-expressing wild-type neurons ...

Electrophysiological study in human brain slices reveals that short-term synaptic plasticity from presynaptic pyramidal neuron to postsynaptic interneuron connections are target-cell specific based on ...

Lipofuscin accumulates in some neurons. Lipofuscin contains peroxidased proteins and lipids and may express the frequent failure of cells to clear these products of peroxidation-induced cell damage ...

At the cellular level, a key pathologic hallmark of NCL is the build-up of autofluorescent storage materials (AFSM) in lysosomes of both neurons and non-neuronal cells. Molecular dissection of the ...