Adding bile acids as farnesoid X receptor agonists to the culture medium supported the growth and development of unique stem ...

Adding bile acids as farnesoid X receptor agonists to the culture medium supported the growth and development of unique stem ...

Hepatic endothelial cells (ECs)—including periportal ECs, liver sinusoidal ECs (LSECs), and central venous ECs—orchestrate regeneration through angiocrine factors like Wnt2 and Wnt9b.

Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising ...

The mechanism of how plant-derived nanovesicles are uptaken by cells remains unknown. In this study, the garlic-derived nanovesicles (GDVs) were isolated and digested with trypsin to remove all ...

Single-cell suspensions were generated using a liver dissociation kit (130-105-807, Miltenyi Biotec, Bergisch Gladbach, Germany), allowing for a high yield of non-parenchymal mouse hepatic cells.

Liver segmentation using deep learning (DL) is a widely discussed topic and this applies for both the modalities Computed Tomography (CT) and Magnetic Resonance Imaging (MR). However, the development ...

The regulatory mechanisms that underlie these phases are common to the development of many organ systems and might be recapitulated or disrupted during stem-cell differentiation and adult tissue ...

Tolvaptan is an effective drug for the treatment of autosomal dominant polycystic kidney disease, but its use is associated with a significant risk of liver injury in a small number of patients.

Cirrhosis represents an advanced stage of liver disease characterised by distorted liver parenchyma, nodule formation, hepatic dysfunction or insufficiency and reduced intrahepatic blood flow leading ...