Therapeutic targeting of the AhR-Siglec-15 axis reveals potent efficacy against SHH medulloblastoma in preclinical models.

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, affecting more than 10 million people worldwide. People with this condition may experience ...

Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is known to regulate cytosolic-side functions such as membrane fusion/fission, ...

The mechanism by which cells detect leaky lysosomes has been revealed, laying the groundwork for new treatments for diseases where lysosomal damage plays a central role. When the cell’s recycling ...

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan ...

The biological world is always expanding as research is constantly being done. Because of this, many findings often fall under the radar despite having the potential to change the world. Here are some ...

Changes in Caenorhabditis elegans lysosome metabolism can be carried through generations via inherited histone modifications. A team of researchers from the Howard Hughes Medical Institute (MD, USA), ...

Lysosomes are thought of as cellular organelles that play an important role in recycling proteins and maintaning cells by breaking down stuff that isn’t needed. But new research has found that ...

Small vesicles enriched in intralumenal endosomal components were more abundant in media from LRRK2 mutant neurons, reflecting increased exocytosis of multivesicular bodies (Fig. 1). Meanwhile, the ...