Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota ...

Some impacts were completely unexpected. For example, synthetic thyroid hormone tiratricol (recently recommended for approval in the EU to treat a rare thyroid condition) was found to also inhibit ...

DNA binding preference of R1335 in SpCas9 vs. xCas9. A. Free energy surface (FES) describing the preference of R1335 for binding either the G3 nucleobase or E1219 in SpCas9. The FES is plotted along ...

Rock and dust samples retrieved by NASA from the asteroid Bennu exhibit some of the chemical building blocks of life, according to research that provides some of the best evidence to date that such ...

All life on Earth is based on carbon and is built from organic compounds including the amino acids used to create proteins and nucleobases. A nucleobase is a nitrogen-containing compound that stores ...

School of the Chemical Science, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India ...

Chromosomal replication must be highly regulated to ensure that the number of chromosomes in the cell remains constant. This means that chromosomal DNA must be replicated only once per cell cycle.

The dynamic structure of RNA plays a central role in post-transcriptional regulation of gene expression such as RNA maturation, degradation, and translation. With the rise of next-generation ...