Elinogrel (PRT060128 or PRT128) (Figure 3) is a direct-acting, reversible P2Y 12 antagonist (Figure 5) that can be administered both intravenously and orally. This unique dual formulation provides ...

The Prescription Drug User Fee Act (PDUFA) date refers to the deadline set by the US Food and Drug Administration (FDA) for reviewing a New Drug Application (NDA) or Biologics License Application (BLA ...

Bentracimab is an investigational human monoclonal antibody fragment that binds to ticagrelor, an oral P2Y 12 platelet inhibitor, reversing its antiplatelet effects. The BLA submission is ...

The new P2Y 12 antagonists, prasugrel and ticagrelor, are characterized by more potent antiplatelet effects and reduce recurrent ischemic event rates compared with clopidogrel among acute coronary ...

Asthma is one of the major growth areas in therapeutics and many new drugs are currently in development. These drugs include improvements of existing classes of drugs, notably once-daily inhaled ...

Antiplatelet therapy and triple therapy in the PCI era Another issue is that nowadays STEMI patients are treated by primary PCI and receive long term dual antiplatelet therapy (including aspirin and a ...

Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling (ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of calcium homeostasis ...

Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States ...

Greater epithelial ridge cells, a transient neonatal cell group in the cochlear duct, which plays a crucial role in the functional maturation of hair cell, structural development of tectorial membrane ...

The circadian rhythm of myocardial infarction (MI) in patients with obstructive sleep apnea (OSA) remains disputable and no studies have directly evaluated the relationship between nocturnal hypoxemia ...

Correspondence to Dr James Douketis, St Joseph’s Healthcare Hamilton, 50 Charlton Ave East, Hamilton, ON L8N 4A6, Canada; jdouket{at}mcmaster.ca To underscore clinical scenarios when anticoagulation ...