We have studied P-selectin glycoprotein ligand (PSGL-1) expression and function in apoptotic monocytic cells. PSGL-1 expression was virtually abolished by proteolytic ectodomain shedding resulting in ...

Agonists of immune checkpoint modulators for treating autoimmune and inflammatory disorders have shown high potential in immunotherapy. P-selectin glycoprotein ligand 1 (PSGL-1) is known to exert ...

They isolated multiple clones encoding PSGL-1. Because PSGL-1 is expressed primarily on leukocytes, it is unlikely to serve as the receptor on nonleukocyte cells, such as neurons.

In inflammatory or thrombotic micro-environments, P-selectin on endothelial cell-derived EVs bind to P-selectin glycoprotein ligand-1 (PSGL-1) on platelets, triggering their transformation from a ...