Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

This process represents a 2-step event that involves initial “platelet rolling” followed by “firm platelet adhesion” on a thrombogenic surface. 3,4 Platelet rolling is mediated by transient ...

Key role of activated platelets in the enhanced adhesion of circulating leucocyte-platelet aggregates to the dysfunctional endothelium in early-stage COPD Patrice Marques 1,2,3† Irene Bocigas 4† Elena ...

Platelet maturation and development involve the expression of receptors on the platelet cell surface. These receptors facilitate platelet adhesion and activation, and they promote thrombus development ...

Despite the effect of lyophilized platelets in promoting the adhesion of fresh platelets on a collagen-coated surface, their net effect was inhibitory on platelet aggregation. This study demonstrates ...

This study used constitutive CD226 gene knockout (KO) mice as a model to investigate the functions and mechanisms of CD226 in megakaryocyte (MK) maturation and platelet activation. Although CD226 ...

The focal adhesion kinase family includes 2 homolog members, FAK and Pyk2 (proline-rich tyrosine kinase 2), primarily known for their roles in nucleated cells as regulators of cytoskeletal dynamics ...

Objective—Cyclophilin A (CyPA) is secreted under inflammatory conditions by various cell types. Whereas the important role of intracellular CyPA for platelet function has been reported, the effect of ...

Interestingly, exposure to 10 μM ADP significantly increased platelet adhesion on the softest 0.5-kPa gels to ∼7,000 platelets per mm 2, and that on gels of 5 kPa to ∼9,500 platelets per mm 2, whereas ...

In addition to being an ideal model for studying the conserved process of exocytosis, platelets are also important players in various physiological processes, including hemostasis, inflammation, and ...