An interdisciplinary research team from Leipzig University and the Saxon AI center ScaDS.AI has developed a novel approach ...

A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific binding and activation of fluorogenic ligands. Traditional protein engineering methods ...

View Full Profile. Learn about our Editorial Policies. Rational design is the classical protein engineering method that involves site directed mutagenesis. 7 Scientists perform specific point ...

Functional protein design, particularly for proteins binding to small molecules such as enzymes and biosensors, is crucial for drug discovery and biomedical applications. Traditional methods based ...

New research uses AI to engineer enzymes with intricate active sites, expanding the possibilities for synthetic biocatalysts.

Yet many modern protein-design methods, including AI-based tools, often ignore how these surroundings influence proteins. This gap limits our ability to create proteins with new functions ...

New research represents a notable step forward in designing enzymes from scratch. With their approach, the authors designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, ...

The described state-of-the-art loop reconstruction method is available free of charge as a module of the academic release version 3.1 of the Rosetta program for protein modeling and design at http ...

Discover how AI tools like AlphaFold and RF Diffusion are revolutionizing protein folding design, medicine, and ...

While AlphaFold and the subsequent AI revolution in biology garnered a lot of attention, the foundational bricks for the strides made in protein structure and design today were laid over the decades .

Wide areas of the pharmaceutical industry are ripe for enhancement, as examples from the industry’s top innovators reflect.

But studying them in their native, natural physiological state, while preserving their 3D protein folds, has proved challenging. Traditional mass spectrometry methods and structural biology ...