This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

Cells can enter a third state only under certain conditions, however, and researchers are still not sure how they can continue to function after the death of the organism.

We have investigated whether dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can trigger B cells to produce antigen-specific antibodies without CD4+ T-cell help ...

The FDA’s ODAC mandates phase assessments for NSCLC trials, dendritic cell immunotherapy shows improved survival in pancreatic cancer, and a new blood test for colorectal cancer receives FDA approval.

A phase 1/2 study investigating a novel dendritic cell-based immunotherapy in patients with resected pancreatic cancer met its primary end point of a 2-year relapse-free survival (RFS) rate of at ...

The Food and Drug Administration (FDA) has granted Fast Track designation to Diakonos Oncology’s investigational dendritic cell vaccine (DCV) for the treatment of pancreatic adenocarcinoma.

More information: Raymond J. Lim et al, CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer, Cell Reports Medicine (2024).

The figure shows the complex organization of dendritic cells in the lymph node. Blood vessels are shown in blue. The cells in green are young dendritic cells whereas the dendritic cells in red are a ...

For their experiments, the researchers examined dendritic cells in an early stage of cell development, known as progenitor cells, allowing them to develop first into immature and then mature ...

Dendritic cells (DCs) are specialized myeloid cells with the ability to uptake, process, and present antigens to T lymphocytes; they also generate cytokine and chemokine gradients that regulate ...