In mice, at about embryonic day (E) 8.5, these cells begin to take on the characteristics of radial glia. During the ensuing phase of neurogenesis, the radial glial cells divide asymmetrically to ...

producing a self-renewing radial glial cell that remains in the VZ and a cell that differentiates into a neuron or an intermediate progenitor. How these differing fates are determined was unknown ...

Cortical formation in the developing brain is a highly complicated process involving neuronal production (through symmetric or asymmetric cell division) interaction of radial glia with neuronal ...

This dissertation focuses on the glial protein GFAP and Alexander disease, a severe neurological disorder primarily affecting young children. Mutations in the GFAP gene disrupt astrocyte function, ...