But in May 2024, she got hired at Brandy Melville after applying “like 20 times.” (This made her mom “so happy,” she says, ...

Alzheimer’s may be driven by more than just plaques—scientists have discovered 200+ hidden proteins that could be quietly harming the brain.

For decades, the story of Alzheimer's research has been dominated by a battle between A-beta and tau amyloids, both of which ...

For decades, the story of Alzheimer’s research has been dominated by a battle between amyloid-beta and tau amyloids, both of ...

A surprising new study has uncovered over 200 misfolded proteins in the brains of aging rats with cognitive decline, beyond the infamous amyloid and tau plaques long blamed for Alzheimer’s. These ...

为解决老龄化社会中认知衰退的分子机制问题，研究人员利用有限蛋白酶解质谱（LiP-MS）技术，在认知表征的老化大鼠模型中，开展了海马区可溶性蛋白质构变化研究。结果显示，214个认知相关结构变化（CASC）蛋白表现出显著降低的自发重折叠能力，表明非共价构象变化是认知衰退的关键特征。该研究发表于《Science Advances》，为神经退行性疾病提供了新靶点与诊断策略。

我们早已知道，在典型的阿尔茨海默病（AD）患者脑中，会出现大脑皮层萎缩、β-淀粉样斑块和tau缠结等“肉眼可见”的病理特征。但现实并非总是如此，一些高龄个体即使没有出现这些典型病变，依然会出现明显的认知衰退。

在全球范围内被广泛使用的神经止痛药物——加巴喷丁（Gabapentin），2025年7月10日发表在BMJ的子刊《RAPM》，研究指出长期使用可能与痴呆症和认知障碍风险增加相关。

Deborah Eckland stood in front of section 47 at the New Hampshire State Veterans Cemetery, facing a small crowd of about a ...