Therefore, in this work, an optogenetic stimulation matrix controllable from a graphical user interface has been developed for its use with a standard 24-well plate for an inverted confocal microscope ...

Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe successful efforts to design improved sAC ...

The enzymatic domain (A1) is delivered into the cytosol and blocks G Sα by ADP ribosylation leading to a permanent stimulation of adenyl cyclase, accumulation of cAMP and active secretion of ...

An elucidation of the role of the neurotransmitter adenosine and the adenosinergic system in drug addiction and withdrawal syndromes may lead to new therapeutics based on the adenosinergic concept.

It can be concluded that the benzopyrone portion of the flavonoids binds at the adenyl site and the phenyl ring B at the ribosyl site. The Walker A and B motifs, intervening sequences, and small ...