Vitamin D is much needed for bone health, supporting immunity, regulating mood, and inflammation-- thus making it important ...

Volume 17, Issue 5, on May 20, 2025, titled "Short-term moderate caloric restriction in the rhesus macaque attenuates markers ...

多项研究表明泛素化有助于不同癌症的发展。USP10在肿瘤进展中发挥着复杂的作用，在不同癌症中既可以作为肿瘤促进因子，也可以作为肿瘤抑制因子。目前的研究表明，USP10 可促进胰腺导管腺癌（PDAC）的发展。因此，USP10 是一个有吸引力的治疗靶点，其在 PDAC 中的功能分子机制值得进一步探索。此外，PLK1 在多种癌症中作为肿瘤促进因子发挥作用，并调节自噬。尽管在不同癌症中 PLK1 ...

Background The role of club cells in the pathology of idiopathic pulmonary fibrosis (IPF) is not well understood. Protein disulfide isomerase A3 (PDIA3), an endoplasmic reticulum-based redox chaperone ...

Figure 6. BTLA agonist treatment attenuates Th17 activation in vitro. (A) Naïve CD3 + CD4 + CD44 low T cells were isolated from C57BL/6 mice and cultured with bound anti-CD3, soluble CD28, rmIL-6, ...

Endothelial EPAS1 attenuates atherosclerosis at sites of disturbed flow by maintaining EC proliferation via fatty acid uptake and metabolism. This endothelial repair pathway is inhibited in obesity, ...

Foxp1 attenuates the HIF-1α signaling response in radial glia Previous reports demonstrated that HIF-1α expression is destabilized between E11.5 and E12.5 (Lange et al, 2016). Using IHC, we analyzed ...

Depression is one of the most serious mental disorders affecting modern human life and is often caused by chronic stress. Dopamine system dysfunction is proposed to contribute to the pathophysiology ...

Depression is one of the most serious mental disorders affecting modern human life and is often caused by chronic stress. Dopamine system dysfunction is proposed to contribute to the pathophysiology ...

Dominant motor control theories propose that the brain predicts and attenuates the somatosensory consequences of actions, referred to as somatosensory attenuation. Support comes from psychophysical ...

Objective The current treatment for hepatocellular carcinoma (HCC) to block angiogenesis and immunosuppression provides some benefits only for a subset of patients with HCC, thus optimised therapeutic ...

If ASD attenuates Dualism, then people with ASD should consider psychological traits as more strongly embodied, hence, as more likely to transfer to the bodily replica. In Experiment 2, participants ...