Treatment with tuspetinib in combination with Venclexta and Vidaza in newly diagnosed acute myeloid leukemia showed safety ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on DNA replication. KDM1A promotes survival in DAC-treated cells via DNA ...

Two examples of these types of drugs are 5-azacytidine and 5-aza-2′-deoxycytidine (Egger et al., 2004). These medications work by acting like the nucleotide cytosine and incorporating themselves ...

In recent years, immunotherapy has become a hot spot in the treatment of tumors. As an emerging treatment, it solves many problems in traditional cancer treatment and has now become the main method ...

Autoimmune diseases comprise a large group of conditions characterized by a complex pathogenesis and significant heterogeneity in their clinical manifestations. Advances in sequencing technology have ...

Here, the authors developed a cell-based screening assay for the identification of small molecule inhibitors of nonsense-mediated decay (NMD), and used it to validate KVS0001, a new small molecule ...

2 Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary 4 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary 5 Heart and ...

The Plinia (ex Myrciaria) genus is a member of the Myrtaceae family and contains several species and hybrids such as Plinia peruviana, P. jaboticaba and P. cauliflora, among others, popularly known as ...