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What Are CD4 T Helper Cells and Why Are They Important?
CD4 T helper cells are a type of white blood cell called a lymphocyte that serves an important role in your immune system. These cells help defend the body against infection by directing other ...
Immune response that may stop breast cancer from spreading identified
A new Moffitt Cancer Center study has identified a specific immune response that may prevent the spread of breast cancer ...
emjreviews.com1h
New mRNA Vaccine Boosts TB Protection
A new LNP-mRNA vaccine significantly boosts immune response and enhances BCG protection against tuberculosis, offering a ...
Aidsmap10y
CD4 and viral load
It’s important for all people with HIV to have regular blood tests. The two most important blood tests are for CD4 and viral load. CD4 and viral load test results give essential information about the ...
Aidsmap2y
What is the normal CD4 count for someone taking HIV treatment?
Most HIV-negative adults have between 500 and 1500 CD4 cells in a cubic millimeter of blood. Most people with HIV who have an undetectable viral load can reach the normal range and often it is only a ...
The Scientist11y
How HIV Destroys Immune Cells
Two research teams led by Warner Greene at the Gladstone Institutes in San Francisco have demonstrated that the vast majority of CD4 T cells in lymphoid tissues, despite their ability to resist full ...
EurekAlert!8d
Moffitt study identifies immune response that may stop breast cancer from spreading
A new Moffitt Cancer Center study has identified a specific immune response that may prevent the spread of breast cancer cells within the body. Published in Cancer Immunology Research, the study shows ...
Nature9y
Preclinical targeting of human T-cell malignancies using CD4-specific chimeric antigen receptor (CAR)-engineered T cells
Here we have designed a CAR, CD4CAR, which redirects the antigen specificity of CD8+ cytotoxic T cells to CD4-expressing cells. CD4CAR T cells derived from human peripheral blood mononuclear cells ...
The New England Journal of Medicine20d
CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53
S3). Immunohistochemical analysis showed a dense lymphocytic infiltration of the lamina propria positive for T-cell receptor (TCR) α, CD3, CD4, and granzyme B but which did not express TRBC1 ...
eLife5d
Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early Infection
This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...
Nature8y
HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation
We show herein that primary in vitro stimulation of CD45RA-selected CD4 T cells of stem-cell donors with 10/10 HLA-matched AML blasts results in expansion of cytolytic T-lymphocytes (CTL ...