Histone deacetylase (HDAC) inhibitors, which are approved for the treatment of cutaneous T-cell lymphoma and multiple myeloma, are undergoing evaluation in other lymphoid neoplasms. How they kill ...

Plant phototropism—directional growth in response to light—serves as a key adaptive mechanism, optimizing photosynthesis and ...

Histone deacetylase (HDAC) enzymes play a critical role in normal gene-regulation events and the maintenance of homeostasis. However, their dysregulation has been implicated in a variety of ...

Histone deacetylase inhibitors may also be used in combination with other cancer treatments such as radiation therapy, chemotherapy, epigenetic therapy and other biological and targeted therapies.

Purpose To determine the safety, dosing schedules, pharmacokinetic profile, and biologic effect of orally administered histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in patients ...

Histone deacetylase (HDAC) antibodies have been used in these testing scenarios, specifically, they have been used to uncover protein interactions related to the development of cancer.

This phase I trial evaluated epigenetic modulation of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor by using a histone deacetylase abexinostat in combination with pazopanib to ...

Histone deacetylase inhibitors enhance immunotherapy in lung cancer models, say researchers. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2016 / 03 / 160331183130.htm.

Ito, K, Ito, M, Elliott, WM, et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med 2005;352:1967-1976 ...

Schematic illustration of potential therapeutic effects of histone deacetylase inhibitors in endometriosis. HDACI: Histone deacetylase inhibitor. Modified from Figure 22.1 in [143].

The desirable properties of histone deacetylase inhibitors (HDACIs) as therapeutics for treating endometriosis are enumerated and the obstacles in testing histone deacetylases (HDACs) in clinical ...