helsinki.fi Objectives: The eventual role of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis was studied in erosive rheumatoid arthritis (RA) and in vitro. Methods: ADAM8 protein ...

A disintegrin and metalloproteinase 17 (ADAM-17) has multiple pathophysiological functions in Alzheimer's disease (AD). However, the clinical relevance of ADAM-17 in AD is not clear yet.This study ...

Background: Loss of articular cartilage is one of the major signs of osteoarthritis (OA). Aggrecan, the main proteoglycan component of the extracellular matrix of articular cartilage is cleaved by ...

Mertk, Mer tyrosine kinase; sMer, soluble MER; LRP1, Low-density lipoprotein receptor-related protein 1; ADAM17, A disintegrin and metalloprotease 17; ox-LDL, oxidized low density lipoprotein; Irf5, ...

We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases) are major ...

而血栓性血小板减少性紫癜（TTP）是一种罕见却危及生命的血液疾病。它的典型特征包括发热、溶血性贫血、血小板减少，以及肾脏和神经功能障碍。TTP 的发病机制主要是 ADAMTS13（a disintegrin and metalloproteinase with thrombospondin motif 13，一种带有血小板反应蛋白基序 13 的解聚素和金属蛋白酶）缺乏，这会导致广泛的微血管血栓形成 ...

To summarize, proteomic analyses and immunohistochemistry results support the hypothesis of aberrant tumor-cell expression of GPIIB. Other cell-surface proteins (e.g., integrins α 6 and β 1 or a ...

1 Department of Internal Medicine, Policlinico IRCCS San Donato, University of Milan, Via Morandi, 30, 20097 San Donato (MI), Italy 2 Department of Internal Medicine ...

University of P. J. Safarik in Kosice, Faculty of Sciences, Institute of Chemistry, Department of Physical Chemistry, Moyzesova 11, 041 01 Kosice, Slovakia ...

Department of Pathology and Laboratory Medicine (S.L., Z.W., L.Z., X.Z., X.L.Z.) and Institute of Reproductive Medicine and Developmental Sciences (S.L., L.Z., X.Z ...

8 Institute of Pathology, University Medical Center Schleswig-Holstein, Lübeck, Germany 9 Institute of Pathology, University Medical Center Schleswig-Holstein, Kiel, Germany Correspondence to Dr ...