The eukaryotic translation initiation factor 4E (eIF4E) controls gene expression through its effects on mRNA export and cap‐dependent translation, both of which contribute to its oncogenic potential.

然而现有eIF4E/eIF4G相互作用抑制剂如4EGI-1存在疗效和选择性局限，亟需开发新型抑制剂。 中国研究人员通过药效团杂交策略，将肼基噻唑与呋喃环结构整合，设计合成42种新型化合物。

Gemin5 and eIF4E co-localized to cytoplasmic P-bodies in human osteosarcoma U2OS cells. Interaction between eIF4E and Gemin5 and their co-localization to the P-bodies, may serve to recruit capped ...

Our MD simulation is supported by available data showing that binding of CYFIP1 to eIF4E and binding to the WRC are mutually exclusive and that there is fluorescence resonance energy transfer between ...

The synthetic lethality between eIF2A and eIF4E (Komar et al., 2005) is interesting in this regard since eIF4E is also involved in the nuclear export of transcripts with 4E-SE elements. This raises ...

Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.

除直接靶向病毒外，两种技术均可沉默宿主易感基因（如翻译起始因子eIF4E）。 通过编辑烟草eIF4E基因座，CRISPR使植株对马铃薯Y病毒 (PVY)抗性提升5倍；RNAi介导的番茄SlTOM1基因沉默则显著降低烟草花叶病毒 (TMV)复制效率。

Among other functions, mTOR phosphorylates proteins involved in translation regulation including S6K and 4E-BP1 (eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1). This mTOR ...

Together, we conclude that ANGEL2 modulates the EIF4E–RNA-binding motif protein 38 complex to enhance WT TP53 translation, and furthermore, the Pep7 peptide may be explored as a therapeutic strategy ...