eIF4E 家族在真核生物的翻译起始过程中具有重要地位，其蛋白质多样性体现在不同生物体的异构体差异、结构特点以及功能的多样性上。eIF4E 在肿瘤发生、应激反应和病毒感染等过程中都发挥着关键作用，同时，其功能受到多种精细调控机制的调节。

Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also ...

研究发现，eIF4E与帽端的结合可以通过eIF4G进一步稳定，同时引导eIF4A在正确的区域展开解旋活动。 而这种协作不仅提高了翻译效率，也赋予了翻译 ...

研究发现，eIF4E与帽端的结合可以通过eIF4G进一步稳定，同时引导eIF4A在正确的区域展开解旋活动。 而这种协作不仅提高了翻译效率，也赋予了翻译 ...

RESULTS: All 65 patients had elevated levels of eIF4E in the tumors. Thirty-six patients (55%) had elevated eIF4E in histologically tumor-free margins, and 20 of these patients (56%) have had ...

The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well as others.

About eIF4E. Eukaryotic translation initiation factor 4E (eIF4E), the main regulatory component of cap-dependent mRNA translation, selectively promotes pro-oncogenic protein synthesis in response ...

Ribometrix Inc. recently discussed the discovery and preclinical evaluation of a novel potent and selective eukaryotic translation initiation factor 4E (eiF4E) inhibitor, RBX-6610, being developed for ...

DURHAM, N.C.--(BUSINESS WIRE)--Ribometrix, a biotechnology company developing small molecule therapeutics that modulate RNA biology, presented the latest data from its eIF4E program at the ...

Several investigations on crop and model plants have confirmed that VPg-eIF4E/(iso)4E interaction is necessary for potyvirus infection. We investigated the functions of the VPg-eIF(iso)4E interaction ...