The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably metastatic tumor cells and migrating leukocytes. Here we report the cDNA ...

Heparanase levels were significantly elevated in tongue cancer patients, suggesting that it might be useful as a diagnostic tool to monitor progression of this disease and response to treatment.

Synthetic heparanase inhibitors: Research team develops alternative method for the treatment of herpes by Geert-Jan Boons, Wiley Editors' notes ...

While more research is needed to understand the most effective way of inhibiting heparanase to prevent viral reinfections, these findings indicate that blocking the protein could be a promising ...

Keeping herpes in check Synthetic heparanase inhibitors inhibit the spread of herpes viruses in tissue Date: September 7, 2023 Source: Wiley Summary: Herpes is not only unpleasant but it can, in ...

Researchers at Radboud University Medical Center in the Netherlands reported an increase of heparanase activity and heparan sulfate levels in the plasma of patients with coronavirus disease (COVID ...

A research team from China developed short hairpin RNA against heparanase (HPA), and determined its effects on HPA expression and the malignant characteristics of gastric cancer cells. Their study ...

Ralph Sanderson. Ph.D., Endowed Professor of Cancer Pathobiology and Division Director, Molecular and Cellular Pathology, recently co-authored and edited the book Heparanase along with Israel ...

Boosting islet heparan sulfate or inhibiting heparanase prevents development of disease. Scientists suggest that either boosting pancreatic islet levels of heparan sulfate (HS) or administering an ...

Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of gastric cancers. Although their efficiencies in inhibiting the ...

Cure may be on the horizon for mesothelioma Israeli and American researchers successfully halted the growth of mesothelioma in model animals by inhibiting the heparanase enzyme.