The beautiful, fascinating and often perplexing world around us grows from intricate and convoluted interactions of millions ...

《Chem》：Rapid generation of hypervariable chemical libraries 【字体： 大 中 小 】 时间：2025年04月07日 来源：Chem 19.1 编辑推荐： 在组合聚酰胺文库用于基于筛选的药物发现中，传统生成方法存在诸多局限。 研究人员开展了利用半自动化流动平台合成组合聚酰胺文库的研究。

Wahls, W.P., Wallace, L.J. and Moore, P.D. (1990) Hypervariable Minisatellite DNA Is a Hotspot for Homologous Recombination in Human Cells. Cell, 60, 95-103.

Then, the researchers scored how well the model could generate a representation for hypervariable regions of known antibody structures, testing its accuracy and training it to improve.

Hypervariable regions vary in length but usually contain fewer than 40 amino acids. It has been estimated that the human immune system can produce up to 1 quintillion different antibodies by changing ...

Researchers developed AbMAP, a cutting-edge framework leveraging transfer learning to model antibody hypervariable regions, significantly improving design and immune repertoire analysis.

We provide evidence of a life–course relationship between gut microbiome profiles and metabolic health.

These results inform and support a programme of clinical evaluations of the HIVconsvX T-cell vaccines together with other cutting-edge tools for HIV-1 cure and prevention such as latency reactivating ...

A library targeting the V4 hypervariable region of the 16S rRNA gene was constructed. After quality control, next-generation sequencing was performed with the Illumina NextSeq platform to analyze ...

Allele frequency distributions of six hypervariable loci (D1S80, APOB, D4S43, vW1, F13A and DYS19) in two African-Brazilian communities from the Amazon region ...

Differentiation between acute and chronic HCV infections is clinically important given that early treatment of infected patients leads to high rates of sustained virological response. Analysis of HVR1 ...

(d) For datasets without pre-defined sample labels or with highly sophisticated sample labels (covering multiple cellular states or disease types), hypervariable analysis can be applied to identify ...