Parapyruvate is a substance commonly found in commercial dietary supplements of calcium pyruvate (DSCP) that inhibits the α-ketoglutarate dehydrogenase complex (KGDHC) and has been shown to induce ...

The intrahippocampal kainate (IHK) model of epilepsy captures key markers of human TLE – animals exhibit hippocampal sclerosis, mossy fiber sprouting, and spontaneous limbic seizures (19, 20). Despite ...

Lactulose and trehalose were applied individually to mice before a bilateral intrahippocampal CA1 injection of oligomeric Aβ 25–35. The administration of lactulose and trehalose attenuated the ...

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Thus, the authors use the existing intrahippocampal kainic acid (IHKA) mouse model, which can have very unpredictable seizures with long periods of time between seizures. This approach is of clear ...