Lactulose and trehalose were applied individually to mice before a bilateral intrahippocampal CA1 injection of oligomeric Aβ 25–35. The administration of lactulose and trehalose attenuated the ...

Intrahippocampal injection of microglia-derived ASC specks leads to amyloid β (Aβ) cross-seeding in mice overexpressing Amyloid-β Precursor Protein and Presenilin-1 (APP/PS1; Pycard+/+ mice) which is ...

Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapy candidates for the treatment of neurological disorders, today announced the publication of the ...

Dubue, J., McKinney, T., Treit, D. and Dickson, C. (2015) Intrahippocampal Anisomycin Impairs Spatial Performance on the Morris Water Maze. Journal of Neuroscience ...

We built a regression model to describe the progress of epileptogenesis in a rat intrahippocampal tetanus toxin (TeNT) epilepsy model by identifying informative neural features from hippocampal local ...

Contrary to popular assumption that areas of the brain responsible for memory are fully matured by age six, researchers report the maturation process continues until the age of at least 14.

As EEG recordings are the most powerful read-outs in animal models of epilepsy, we evaluated the use of wireless radio-telemetry in the intrahippocampal post-status epilepticus kainic acid model, an ...

Lack of scientific reproducibility is a growing concern and weak experimental practices may contribute to irreproducibility. Here, we describe an optimized and versatile protocol for stereotaxic ...

To assess which part of intrahippocampal circuitry is essential for modulation of anxiety and fear, we thus used a mixed genetic-pharmacological approach: We systemically administered a nonselective ...

The hippocampus features a double dissociation in its circuits with respect to the regulation of fear and anxiety, with CA3 and the dentate gyrus implicated in anxiety and CA1 in fear.

In vitro and in vivo studies show that levels of lactate available to neurons affects susceptibility to epileptic seizure, a finding consistent with the beneficial effect of a ketogenic diet to tre ...