Given that the role of PRMT1 in metabolic regulation has been well-documented, we then investigated whether PRMT1 is involved in transforming 6133 cells through metabolic reprogramming. To assess this ...

In mouse AML cells, some genes critical in leukemogenesis, including Myc, Meis1, and Runx2, are also super-enhancer-associated genes (8), which indicates that super-enhancers may dedicate to AML ...

1Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, China. 2Department of Hepatobiliary Surgery,Centre for Leading Medicine and Advanced Technologies of IHM, The First ...

Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells ...

This month's cover highlights the article DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging by Sara Sepe, Francesca Rossiello, Fabrizio d’Adda di ...

For lentivirus production, HEK293T cells were transfected with the CS–Hes1 or mock plasmid together with the psPAX2 packaging plasmid and the pMD2.G envelope plasmid, and the concentrated ...

Murine hematopoietic cells were transduced with ecotropic supernatants (Figure 1b), using conditions that led to efficient gene marking with low provirus copies (<3) per cell. 23 Polyclonal ...