This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The ...

Here are five major benefits of office hysteroscopy when managing common gynaecological conditions: Office hysteroscopy ...

A team led by the University of Sydney has identified red blood cell rupture at dying endothelial sites as a primary driver of microvascular obstruction in COVID-19, bypassing the expected role of ...

Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network ...

Resuspended cells were lysed by two passages through a microfluidizer (Analytik, UK) and subjected to centrifugation at 41,000 r.p.m. for 50 min at 4°C.

imageimageFerroptosis is an iron-dependent form of programmed cell death that is driven by the accumulation of toxic lipid hydroperoxides. This study uncovers regulation of ferroptosis by the citrate ...

Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells ...

imageimageThe split intein-mediated protein ligation (SIMPL) system for detecting protein-protein interactions has been enhanced by incorporating tri-part Nanoluciferase. This updated system, called ...

Lysed erythrocyte membranes enhanced calcification to a similar extent as the NO donor diethylenetriamine-NO, and their osteoinductive effects could be further augmented by arginase-1 inhibition ...

Department of Immunology & Microbial Disease, Albany Medical College, Albany, NY, United States Although considered the ternary inflammasome structure, whether the singular, perinuclear NLRP3:ASC ...