No longer a mere assistant who carries out the commands of DNA, RNA takes the lead in emerging therapeutics.

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where ...

Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

A new understanding of how tumours exploit our nervous system is leading to new ways to treat cancer using familiar drugs ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized ...

The new CBC-ALYREF structure revealed molecular insights into the ALYREF-mediated recruitment of mRNA export machinery to the 5' end of nascent mRNA transcripts. The structure, along with biochemical ...

For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.

A naturally occurring miR-499 mutation outside the critical seed sequence modifies mRNA targeting and end-organ function. This first description of in vivo effects from a natural human miR mutation ...

Clarifying the structure and function of the triggers of the RNAi machinery and developing RNA-delivery technologies will increase the applicability of RNAi to biology and medicine.