This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger ...

Long noncoding RNAs (lncRNAs) could be a byproduct of transcription (i), a scaffold linking proteins (ii) or a guide bringing proteins to specified parts of the genome (iii).

The abundance of conserved noncoding regions holds even for so-called ultraconserved elements at the very tip of the mammalian conservation scale 2, as well as for sequences conserved between long ...

The most commonly recognized function of RNA is to code for proteins in the body, but 75% of the human genome generates noncoding RNA that does not code for proteins. A substantial portion of these ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

To identify noncoding mutations that are associated with functional effects in cancer, Dr. Ideker’s team turned back to TCGA data and carried out a systematic analysis of 930 tumors, integrating ...

Noncoding RNAs as master regulators in brain. According to Debra Silver, a developmental neurobiologist at the Duke University School of Medicine in North Carolina, researchers have for nearly half a ...

Noncoding mutations contribute to autism risk Date: December 13, 2018 Source: Simons Foundation Summary: A whole-genome sequencing study of nearly 2,000 families has implicated mutations in ...

New research shows modifying noncoding RNA with N6-methyladenosine allows the RNA exosome to recognize a specific noncoding RNA associated with the genomic site that encodes the heavy chain of ...

Definitions Box: Long noncoding RNAs (lncRNAs) are RNAs longer than 200 nucleotides that do not contain any open reading frames greater than 300 nucleotides (100 codons). The DNA sequences they’re ...