Target validation is the process by which the predicted molecular target – for example protein or nucleic acid – of a small molecule is verified. Target validation can include: determining the ...

A virus originally found in animals, mpox – which causes the disease of the same name – is now circulating in humans.

Researchers at the Institut Pasteur have uncovered how mpox virus mutations make it resistant to tecovirimat, the primary ...

Key ribosomal proteins, RACK1 and RPLP2, were identified as crucial for late-stage poxvirus mRNA translation, with RPLP2 playing a significant role in the ribosome's P-stalk extension. This ...

Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins. Based on their functional domains and ...

As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response ...