The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress responses alter the ...

The endoplasmic reticulum (ER)-localized transmembrane proteins IRE1, PERK and ATF6 detect the load of unfolded protein in the lumen of the organelle, serving as stress receptors. They transduce ...

A further understanding of the organelle could pave the way for better treatment of genetic and neurodegenerative diseases.

Professor Rainer Hedrich, biophysicist at Julius-Maximilians-Universität (JMU) Würzburg The Würzburg plant scientists were ...

This is another new finding because scientists have previously found CTR1 only within a network of cellular membranes called the endoplasmic reticulum, with some translocation to the nucleus under ...

Department of Nephrology, The Second Hospital of Zhuzhou City, Zhuzhou, Hunan, China The endoplasmic reticulum (ER) is the most metabolically active organelle in cells, and recent research has shown ...

Diabetic cardiomyopathy (DCM) is a critical complication of diabetes, the accurate pathogenesis of which remains elusive. It is widely accepted that endoplasmic reticulum (ER) stress and abnormal ...

Scientists at the University of Western Australia and the Perron Institute for Neurological and Translational Science have ...

SGT-501 is a novel gene therapy for rare, life-threatening, genetic arrhythmogenic disease with no approved therapies - - SGT-501 has rec ...

Scientists have made a groundbreaking discovery in the realm of human cell biology. Through the use of cryo-electron ...

BACKGROUND: Pathological cardiac remodeling after myocardial infarction (MI) is a leading cause of heart failure and sudden death. The detailed mechanisms underlying the transition to heart failure ...