We estimated age-standardized cancer incidence (2010–2019) and mortality rates (2010–2022) in the United States to investigate whether cancer rates have increased at younger ages. Fourteen cancers had ...

Historical studies performed nearly a century ago using mouse skin models identified two key steps in cancer evolution: initiation, a likely mutational event, and promotion, driven by inflammation and ...

2019 Meetings Abstracts: AACR Special Conference on Modernizing Population Sciences in the Digital Age February 19–22, 2019; San Diego, CA Proceedings: AACR Annual Meeting 2019 March 29–April 3, 2019; ...

AbstractBackground:. Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphoblastic leukemia (ALL).Methods:. We conducted a ...

Mitochondria are central hubs for generating energy and biosynthetic intermediates (5). In cancer cells, the importance of mitochondrial metabolism has often been overlooked in favor of increased ...

Our laboratory previously examined the effects of walnuts on mouse models of intestinal disease (6 – 9). Using the colon carcinogen azoxymethane, we tested the effects of walnuts added to Total ...

AbstractPurpose:. Advanced prostate cancer is invariably fatal, with the androgen receptor (AR) being a major therapeutic target. AR signaling inhibitors have improved overall survival for men with ...

Approved inhibitors of KRAS G12C prevent oncogenic activation by sequestering the inactive, GDP-bound (OFF) form rather than directly binding and inhibiting the active, GTP-bound (ON) form. This ...

Although previous work had focused on the development of T cell–engaging therapies, clinical development of T cell–based therapeutics remains challenging for solid tumors due to tumor heterogeneity, ...

Mutations in ERBB2 (encoding HER2) occur in 2% to 4% of non–small cell lung cancer (NSCLC) and confer poor prognosis. ERBB-targeting tyrosine kinase inhibitors, approved for treating other ...

Upon cancer therapy, a fraction of cancer cells often evade cell death by entering into a proliferative arrest and potentially contributing to tumor relapse (1). It is possible to distinguish at least ...