In this randomized controlled trial, patients with resected stage III or high-risk stage II colon cancer who completed ...

1. Median overall survival was 13.6 months in the tarlatamab group and 8.3 months in the chemotherapy group, with HR 0.60 (significant) 2. Adverse events grade 3 or higher occurred in 54% of the ...

In-depth [randomized controlled trial]: Between Jun 8, 2018, and Oct 25, 2022, 25,129 patients were assessed for eligibility across 106 hospitals in England, Scotland, and Wales. Included were ...

1. The use of dapagliflozin in patients with metabolic dysfunction-associated steatohepatitis (MASH) resulted in a higher proportion of improvement of MASH compared to placebo. Evidence Rating Level: ...

In-depth [randomized controlled trial]: Between Jan 6, 2020, and Nov 8, 2021, 1148 patients were assessed for eligibility across 163 hospitals in 25 countries. Included were patients ≥ 18 with ...

1. In this randomized controlled trial, prophylactic treatment with trimethoprim-sulfamethoxazole (TMP-SMX) was not associated with a reduction in the incidence of prematurity or small-for-gestational ...

1. In this randomized trial, upadacitinib dosed at 15mg with a 26-week glucocorticoid taper showed superior efficacy than placebo with a 52-week glucocorticoid taper for sustained remission of giant ...

1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second diagnostic block does not improve post-radiofrequency ablation pain outcomes but may ...

1. Respiratory outcomes for preterm infants with a patent ductus arteriosus (PDA) undergoing transcatheter closure compared to surgical ligation did not differ. Evidence Rating Level: 2 (Good) ...

1. Frailty scores alone (mFI-5, CCI) are poor predictors of intensive care unit (ICU) admission or prolonged hospital stay in elderly patients undergoing diverse elective surgeries Evidence Rating ...

1. Routine single-session screening for emotional and cognitive issues post-stroke does not improve long-term societal participation but may offer modest early benefits in anxiety and quality of life ...

1. Rectoscopy alone for evaluation of endoscopic and histologic remission of ulcerative colitis (UC) had good accuracy and is sufficient for use in clinical practice. Evidence Rating Level: 2 (Good) ...